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Spravato / Ketamine

Spravato is an FDA-approved nasal spray that is covered by most insurances for:

Spravato Nasal Spray

What is Spravato?

Spravato (esketamine) CIII nasal spray is a prescription medicine that is used alongside antidepressants to treat adults with treatment-resistant depression (TRD) and major depressive disorder (MDD). It is the first FDA-approved nasal spray specifically for adults with depression.

More information about Spravato, its uses, risks, and potential benefits are available in this informational video, below:

Spravato Works

Ask the Experts
Top doctors answer your top questions about Spravato. 

Direct link: https://spravato.brightcovegallery.com/ask-the-expert

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Does Spravato Work?

Clinical studies demonstrate that individuals who took Spravato along with oral antidepressants experienced greater reductions of symptoms compared to those who only received an oral antidepressant and a placebo.  Studies further demonstrated that patients who took Spravato and participated in therapy were less likely to experience a return of depressive symptoms than those who stopped participating in therapy.

What to Expect as a Spravato Patient

A typical course of Spravato treatment includes:

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Will My Insurance Cover Spravato Treatment?

Every insurance company and insurance plan is different.  At Ahwatukee Behavioral Health & Wellness, we’re here to help by simplifying the process and working with your insurance. 

First, we perform a comprehensive evaluation to determine whether you may benefit from Spravato. 

Second, if Spravato is appropriate for you based on your psychiatric provider’s assessment, ABHW staff will contact your insurance to determine your insurance’s coverage guidelines for Spravato.  Most major insurances require: (1) that a patient has a diagnosis of depression, and (2) that a patient has not responded sufficiently to at least two different antidepressants. However, all insurances differ, and the ABHW team will help you understand your benefits. 

Third, after we’ve contacted your insurance, we will discuss your coverage options with you, and what costs, if any, would be associated with your treatment.   

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Are There Side Effects?

There are side effects associated with Spravato, including dissociation, dizziness, nausea, feeling sleepy (sedation), spinning sensation, decreased feeling of sensitivity (numbness), feeling anxious, lack of energy, increased blood pressure, vomiting, feeling drunk, and feeling very happy or excited. If these side effects occur, they typically happen right away after taking Spravato, and go away the same day.  

If you choose to receive Spravato, it will only be administered at ABHW’s offices under the supervision of one of ABHW’s providers who are certified under the Spravato Risk Evaluation and Mitigation Strategy (REMS) program. Your provider will discuss the risks associated with Spravato use and misuse before you begin treatment.

How is Spravato Different from Ketamine?

Ketamine is typically administered either via IV infusion or intramuscular injection.  Moreover, it is not covered by any insurance companies for treatment of depression or depressive symptoms. Therefore, patients receiving ketamine treatments must pay cash. 

Spravato, on the other hand, is covered by most major insurers as a depression treatment. 

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Who Should Not Take Spravato?

You should speak to your provider if you:

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In addition, individuals should not take Spravato if they have:


Spravato has offered relief for individuals with depression above and beyond what they were able to receive from oral antidepressants.  You can hear some of their stories below. 

Schedule a Spravato Assessment Today

During your first visit with one of ABHW’s psychiatric providers, you will receive a comprehensive psychiatric assessment that includes an evaluation of whether Spravato may be an appropriate treatment for you

Have more questions? We'd love to help!