Understanding How Spravato Works: A Guide for Patients

Navigating the world of mental health treatments can be daunting, especially when faced with the complexities of medication options. One such medication gaining attention is Spravato, a nasal spray approved by the FDA for the treatment of treatment-resistant depression (TRD) and major depressive disorder (MDD) with suicidal ideation. But how exactly does Spravato work, and what can patients expect from this innovative treatment? In this comprehensive guide, we delve into the mechanisms behind Spravato’s action, shedding light on its efficacy and safety for patients. From its unique formulation to its administration process, understanding the ins and outs of Spravato is crucial for individuals seeking relief from persistent depressive symptoms. Whether you’re considering Spravato as a treatment option or simply curious about its effects, this guide aims to provide clarity and insight into the workings of this groundbreaking medication. Let’s embark on a journey to demystify Spravato and empower patients in their mental health journey.

What to Expect During Spravato Treatment Sessions

Entering into Spravato treatment can be an important step towards managing your mental health. However, the prospect of undergoing treatment sessions might understandably bring about some uncertainty or apprehension. Understanding what to expect during Spravato treatment sessions can help ease any concerns and prepare you for the journey ahead.

Spravato Treatment Sessions

Initial Assessment and Screening

Before beginning Spravato treatment, you will undergo a thorough assessment and screening process with your healthcare provider. This typically includes a review of your medical history, current medications, and mental health symptoms to ensure that Spravato is a suitable option for you.

Pre-Treatment Preparation

On the day of your treatment session, you will be instructed to abstain from eating or drinking for a certain period beforehand, as advised by your healthcare provider. This is important to ensure the safety and efficacy of the treatment.

Administration of Spravato

Spravato is administered as a nasal spray, and each treatment session typically lasts for about two hours. You will be seated comfortably during the session, and the nasal spray will be administered by a healthcare professional according to the prescribed dosage.

Monitoring Vital Signs

Throughout the treatment session, your vital signs, such as blood pressure and heart rate, will be closely monitored to ensure your safety. Healthcare providers will also be on hand to address any questions or concerns you may have during the session.

Post-Treatment Observation

After receiving the Spravato dose, you will remain under observation for a period of time to monitor for any immediate side effects or adverse reactions. This observation period is important for ensuring your safety before you are cleared to leave the treatment facility.

Long-Term Effects and Considerations of Spravato Treatment

As you embark on Spravato treatment to manage your mental health, it’s essential to consider not only the immediate effects but also the long-term implications. Understanding the potential long-term effects and considerations of Spravato treatment can help you make informed decisions and navigate your mental health journey with confidence.

Sustained Efficacy Over Time

One of the key considerations of Spravato treatment is its long-term efficacy. While many patients experience significant improvement in their symptoms during the initial phases of treatment, it’s essential to discuss with your healthcare provider how the effectiveness of Spravato may be sustained over time.

Risk of Tolerance and Dependence

Like many medications used to manage mental health conditions, there is a risk of developing tolerance to Spravato over time. This means that your body may become accustomed to the medication, requiring higher doses to achieve the same therapeutic effect. Additionally, there is a potential risk of dependence with long-term use of Spravato, which should be carefully monitored by your healthcare provider.

Managing Side Effects Long-Term

While Spravato is generally well-tolerated, some patients may experience side effects that persist over the long term. These may include issues such as headaches, dizziness, or dissociation. It’s important to work closely with your healthcare provider to manage these side effects effectively and ensure they do not impact your quality of life.

Potential Impact on Cognitive Function

Another consideration of long-term Spravato treatment is its potential impact on cognitive function. Some patients may experience changes in memory, concentration, or cognitive processing speed. It’s essential to discuss any cognitive changes with your healthcare provider to determine if adjustments to your treatment plan are necessary.

Psychological Effects and Emotional Well-being

Beyond the physical effects, long-term Spravato treatment may also have psychological implications. Some patients may experience changes in mood, emotions, or perception over time. It’s important to prioritize your emotional well-being and communicate openly with your healthcare provider about any changes you notice.

Navigating the Costs of Spravato Treatment

Understanding the financial aspects of Spravato treatment is crucial for patients seeking mental health support. Let’s explore key points to help navigate the costs associated with this innovative therapy.

  • Insurance Coverage: Investigate whether your health insurance plan covers Spravato treatment. Some plans may fully or partially cover the costs, but it’s essential to check specific details and any requirements for coverage.
  • Out-of-Pocket Expenses: Be prepared for potential out-of-pocket expenses, such as copayments or deductibles. Understanding these costs upfront can help you budget accordingly and avoid any unexpected financial strain.
  • Financial Assistance Programs: Explore available financial assistance programs offered by pharmaceutical companies or non-profit organizations. These programs may provide support for eligible patients to help offset the costs of Spravato treatment.
  • Prior Authorization Requirements: Some insurance plans may require prior authorization before covering Spravato treatment. Work closely with your healthcare provider to navigate this process and ensure timely approval for treatment.


Understanding how Spravato works is essential for patients considering this treatment option for depression. As discussed, Spravato, with its active ingredient esketamine, offers a novel approach to managing treatment-resistant depression by targeting different brain receptors than traditional antidepressants. While its effectiveness and safety have been demonstrated in clinical trials, it’s crucial for patients to discuss potential benefits and risks with their healthcare providers before starting treatment. By staying informed and actively engaging with their healthcare team, patients can make informed decisions about their mental health journey.

If you have any further questions about Spravato or would like to explore treatment options for depression, please don’t hesitate to contact us at Ahwatukee Behavioral Health & Wellness. Located in Phoenix, Arizona, our dedicated team is committed to providing comprehensive mental health care to support you on your path to wellness. You can reach us at [insert phone number] or visit our website for more information. Your mental health matters, and we’re here to help every step of the way.